In This Issue—Confronting Pregnancy Loss

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I-24: New Molecular Aspects in Recurrent Pregnancy Loss

Background Recurrent pregnancy loss (RPL) is usually defined as three or more consecutive pregnancy losses before 20th gestational week. Many etiological factors have been considered as cause of RPL including genetic factors, uterine anatomical defects, endocrine abnormalities, thrombotic and immunologic factors. Nevertheless, the cause of RPL remains unknown in around half of the patients desp...

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Endometrial Granulated Lymphocytes in Women Suffering Spontaneous Early Pregnancy Loss

Spontaneous abortion is the most common complication of pregnancy. Several lines of evidence indicate that immunologic effector cells may play a role in the pathogenesis of idiopathic repetitive abortions. Leukocytes form a substantial proportion of stromal cells in decidua and the endometrial granulated lymphocytes (eGL) is the predominant decidual leukocyte population in the first trimester o...

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Soluble CD30 in Normal Pregnancy Pre-Eclampsia and Recurrent Pregnancy Loss

Background: Normal pregnancy is thought to be dependent on Th2 deviation, while Recurrent Pregnancy Loss (RPL) and Pre-eclampsia (PE) appear to be biased toward the Th1 immune response. It is believed that the soluble form of CD30 (sCD30) is an index of Th2 immune response or modulator of Th1/Th2 responses. Objective: The aim of this study was determination of the sCD30 level in RPL and PE pati...

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Molecular Mechanisms of Recurrent Pregnancy Loss

Introduction: Pregnancy and health is the process in which the egg is fertilized and being able to survive. When pregnancy occurs under some conditions and the fetus is being at risk, it will lead to abortion that occurs involuntarily and spontaneously. Abortions that occur more than two or three times are called recurrent pregnancy loss (RPL). Various etiological factors involved in RPL, inclu...

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Early pregnancy loss.

Pregnancy is a significant event in a woman’s life, and emotional attachment to the pregnancy and developing baby may begin early in the first trimester. For most women, experiencing a first trimester loss is a difficult and vulnerable time. When it occurs, the grief can be as profound as for any perinatal or other major loss [1]. Spontaneous abortion (a pregnancy that ends spontaneously before...

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ژورنال

عنوان ژورنال: The Journal of Perinatal Education

سال: 2020

ISSN: 1058-1243,1548-8519

DOI: 10.1891/1058-1243.29.1.3